Plant genetic transformation

Responsible for the daily management and project management of the laboratory; Plant tissue culture and stable genetic transformation.

3D-genomics; Evolution of Salsola photosynthesis; Machine learning

1. Developed the analysis software of new spatial three-dimensional genome technology, and analyzed the regulation of chromatin three-dimensional conformation on organ development in different developmental stages of mouse embryos.

2. Analyzed the genomic characteristics of different photosynthetic pathways (C3, C4, C3-C4 intermediate) of Salsola plants by comparative genomic and population genetic analysis methods.

Spatial multi-omics

Develop spatial multiomics technology based on microfluidic system; Develop High-order genome interaction capture methods based on nanoparticle assembly; Joint development of robotic equipment for spatial multiomics technology.

Single-cell multi-omics

Comprehensive depiction of complex life development processes is one of the greatest goals in life science research. We plan to integrate single-cell multi-omics technology, involving epigenome, three-dimensional genome, transcriptome, etc., to construct a developmental map of higher animals.

Genomic Evolution

Using various photosynthetic intermediate types of mollugo as materials, analyze the genetic basis of C4 evolution in various stages, and provide genetic resources for the construction of artificial C4 crops.

Single-cell multi-omics; Spatial omicsI 

I primarily focus on the development of high-throughput detection technologies for single-cell DNA epigenetic regulation using cell lines and mouse embryos as models. Simultaneously, I am involved in applying these techniques to spatial omics, aiming to utilize novel technologies to reveal the impact of cellular epigenetic regulation on transcription.

Evolution of C4 photosynthesis in Eleochris

The primary focus of my study involves the C3-C4 intermediate species Eleocharis baldwinii and the C4 species E. retroflexa. I aim to uncover the genetic basis of C4 photosynthesis evolution through comparative genomics and single-cell techniques. Additionally, I will discover the mechanism of core modules how to shape the C4 photosynthesis.

The biosynthesis of C4 photosynthetic rice

Characterization of C4 specific elements and integration of C4 modules to construct C4 photosynthetic rice.

Co-evolution of the Crassulacean Acid Metabolism Pathway and Circadian Rhythm

Focus on the studies about the co-evolution of the crassulacean acid metabolism pathway (CAM) and circadian rhythm: 1. Comparative genomics to clarify the evolutionary characteristics of the CAM; 2. Spatial omics to identify the regulatory network of the metabolomics, transcriptome and chromatin accessibility in the 24-hour circadian rhythm of the CAM; 3. Synthetic biology to verify molecular mechanism of co-evolution of the CAM and circadian rhythm.

Genomic Evolution

Resolve the complex evolution of Poaceae by bioinformatics methods like comparing genomes and transcriptomes; Develop algorithms to dissect plant genome varitions with massive species; Intergarted analysis of single-cell multi-omics data.

Genomic Evolution; Evolution of Photosynthesis

I joined Li Lab in IGDB as a post-graduate student with the major of bioinformatics. Now I am working in plant evolution questions, particularly global landscape of plant genomic evolution and origin of C4 photosynthesis in history.